The aim of present work was to formulate and evaluate Proniosomal gel formulation for treatment of psoriasis. Preformulation study like solubility, melting point was done. Drug and Excipient compatibility was determined by FT-IR spectroscopy and DSC study. Screening study was done for the selection of surfactant and lecithin as well as drug: lipid ratio by preparing Proniosomal gel formulation by co-acervation phase separation method. Span 60 and soya lecithin shows desirable result and it was selected for further optimization. Optimization was done by CCD with different concentration of span 60 and cholesterol. Particle size and entrapment efficiency was measure with other evaluating parameter. Drug diffusion from the proniosomal gel was study using Franz diffusion cell. The release kinetic data were subjected to different models in order to evaluate their release kinetics and mechanism and it follows Higuchi release kinetic model with diffusion base mechanism. Optimized batch F37 [Concentration of span 60(8.00) and concentration of cholesterol (2.00)] was prepared and optimized by center composite design and shows 85.55% drug diffusion in 24 hrs. The optimized batch no 3 was compared with marketed preparation and it shows better sustain release action than marketed preparation. The present study conclude that it is possible to prepare Proniosomal gel of Clobetsol propionate with desired criteria which enhance the permeability, gives the sustain release action and Hence improve the drug effect.
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